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Home > Product > Autophagy

Products of Autophagy Research

Autophagy refers to the process by which non-essential or dysfunctional cellular components are degraded by lysosomes into essential nutrients, such as amino acids, lipids, and sugars. Autophagy serves not only as a specialized mechanism for cells to adapt to extreme environments but also as a crucial regulatory mechanism for normal cellular activities. Abnormal autophagy often plays a significant role in cell damage and aging. Currently, autophagy is known to be involved in various vital biological processes including tumor development, aging, inflammation, immune response, cardio-cerebral vascular diseases, oxidative stress, neurodegenerative diseases, metabolism, and development.

Hanbio Products:

Kinds of Autophagy	Tools		Product Application	Product Offering
Classical autophagy	mCherry-eGFP-LC3			Labels autophagosomes and autolysosomes	LV/Ad/AAV
	eGFP-LC3			Labels autophagosomes	LV/Ad/AAV
	mCherry-LC3			Labels autophagosomes	LV/Ad/AAV
	mCherry-eGFP-LC3（G120A）			LC3 mutant, used as control	LV/Ad/AAV
	eGFP-LC3（G120A）			LC3 mutant, used as control	LV/Ad/AAV
	mCherry-LC3（G120A）			LC3 mutant, used as control	LV/Ad/AAV
Mitophagy	mKeima			For the study of mitophagy phenotype	LV/Ad/AAV
		Cox8-EGFP-mCherry					LV/Ad/AAV
		mito-dsred	EGFP-LC3			LV/Ad/AAV
				Parkin-EGFP	For the study of mitophagy pathway	LV/Ad/AAV
				Bnip3-EGFP			LV/Ad/AAV
				Nix-EGFP			LV/Ad/AAV
				FUNDC1-EGFP			LV/Ad/AAV
ER-phagy	mCherry-EGFP-RAMP4			ER-phagy	LV/Ad/AAV
		mCherry-RAMP4					LV/Ad/AAV
		ssmRFP1-EGFP-KDEL					LV/Ad/AAV
chaperone-mediated autophagy (CMA)	KFERQ-PAmCherry1			Detects CMA activity	LV/Ad/AAV
chaperone-mediated autophagy (CMA)		PAmCherry1-KFERQ-NE		Detects CMA activity			LV/Ad/AAV

Virus of Organelle Location Tool in stock:

Tools	Product Applicatio	Product Offering
mito-dsred	Mitochondrial localizat	LV/Ad
mito-mTur	Mitochondrial localizat	LV/Ad	LV/Ad
Lamp1-RFP	Lysosome localization	LV/Ad
ER-mTur	Endoplasmic reticulum localization	LV/Ad

P62 virus/plasmid in stock

Product Name	Production Scale
Overexpression P62 Ad	10¹⁰PFU/ml，1ml
Overexpression P62 LV	10⁸TU/ml，1ml
Overexpression P62 AAV	10¹²v.g/ml，1ml
Overexpression P62 plasmid	5μg

List of autophagy related gene viruses in stock

Gene Name	Gene Function	Species	Product Offering
ATG５	Binds to ATG16 and ATG12 to form a complex involved in the formation of autophagic vesicles	human/mouse	LV/Ad
ATG7	Binds to and activates ATG12	human/mouse	LV/Ad
ULK1	Forms ULK complex to int	human/mouse	LV/Ad
ULK3	Forms ULK complex to interact with mTOR receptors	human/mouse	LV/Ad
Beclin1/ATG6	Forms a complex with PI3K to regulate autophagic activity	human/mouse	LV/Ad
LKB1	Activates AMPK to activate autophagy	human/mouse	LV/Ad
ULK 2	Forms ULK complex to interact with mTOR receptors	human/mouse	LV/Ad
NBR 1	Autophagy receptor protein	human/mouse	LV/Ad
ATG16L 1	Binds to ATG12 and ATG5 to form a complex involved in the formation of autophagosomes	human/mouse	LV/Ad
ATG 13	Forms ULK1 complex to interact with mTOR receptors	human/mouse	LV/Ad
ATG16L 2	Binds to ATG12 and ATG5 to form a complex involved in the formation of autophagosomes	human/mouse	LV/Ad
ATG 4A	Cleavages LC3 protein to form LC3-I	human/mouse	LV/Ad
ATG 4B	Cleavages LC3 protein to form LC3-I	human/mouse	LV/Ad
ATG 9B	Involved in PAS formation	human/mouse	LV/Ad
EI24	Mediates the fusion of autophagosome and lysosome	human/mouse	LV/Ad
ATG9A	Involved in PAS formation	human/mouse	LV/Ad
ATG14	Binds to vps15 and vps34 to form a complex involved in the formation of membrane vesicles	human/mouse	LV/Ad
ATG3	Processes LC3-I into LC3-II together with ATG7	human/mouse	LV/Ad
ATG4C	Cleavages LC3 protein to form LC3-I	human/mouse	LV/Ad
DRAM2	Inhibits the initiation of autophagy	human/mouse	LV/Ad
ATG4D	Hydrolyzes pro-LC3	human/mouse	LV/Ad
ATG10	Activates ATG12	human/mouse	LV/Ad
DRAM1	Mediates the fusion of autophagosome and lysosome	human/mouse	LV/Ad
ATG101	Binds with ATG13 to avoid ATG13 degradation	human/mouse	LV/Ad
ATG12	Binds to ATG5 and ATG16L1 to form a complex involved in the formation of autophagosomes	human/mouse	LV/Ad
parkin	Key protein of mitochondrial autophagy	human/mouse	LV/Ad
TOMM20	Mitochondrial membrane protein	human/mouse	LV/Ad