Customer Case 1:

University of Science and Technology of China customer Published in CELL, IF=41.582 (2018)

Title: Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain

Methods: A glass micropipette was placed bilaterally into the M2 cortex or CA3 region of the hippocampus and 0.5 uL of virus was infused on each side using a pump at a rate of 50 nl/min. virus titer 1.33×1012 v.g/mL. ¹²  v.g/mL

Figure 5. Effects of UVB Exposure on Glutamatergic Synaptic Transmission from HPC CA3 to CA1

Customer Case 2:

Chinese Academy of Sciences customer Published in Cell Research, IF=25.617 (2018)

Title: METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

Methods: Viruses were delivered at a rate of 0.1 µl/min, and needles were kept still for an additional 1 min before withdrawing, were bilaterally injected into the dorsal hippocampus (relative to bregma: AP = −1.9 mm, ML = ± 1.2 mm, DV = − 1.3 mm). virus titer 1.0-1.2 ×10¹²v.g/ml

Figure7. METTL3-mediated m6A modification in regulating long-term memory

Customer Case 3

Zhejiang University Customer Published in Nature Neuroscience, IF=24.884 (2016)

Title: Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear

Method: AAV2/9 injected 0.3–0.5 µl of virus into each location at 0.05 µl/min, were injected into the right-lateral LDT (AP, −5.2 mm from bregma; ML, −0.4 mm; DV, −3.5 mm). virus titer1.0×10¹²v.g/ml

Figure 4. PV+ and SOM+ interneurons in the LDT oppositely regulate innate fear

Customer Case 1:

Customer of Southern Medical University Published in CELL, IF=41.582 (2019)

Title: LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

Method : AAV9 were injected into mice through tail vein, 100 μl per mouse, virus titer 1.0 × 10¹²v.g/ml

Figure 7. AAV9-LECT2-shRNA Decreases Liver Fibrosis

Customer Case 2:

Customer of Nanjing University Published in Nature Communications, IF=14.949

Title: CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Method : AAV9 were injected into mice through intravenous, virus titer1.0 × 10¹²v.g/ml

Figure 8. CUGBP1 in HSCs promotes murine liver fibrosis induced by BDL

Customer Case 3:

Customer of China Pharmaceutical University Published in Nature Neuroscience, IF=24.884

Title: Angptl8 mediates food-driven resetting of hepatic circadian clock in mice

Method : AAV8 were injected into mice through tail vein, virus titer 1.0 × 10¹²v.g/ml

Figure 9. Angptl8 knockdown dampens the liver clock reset by food

Customer Case 1:

Customer of China Pharmaceutical University Published in European heart journal, IF=29.983

Title: Neuraminidase 1 is a driver of experimental cardiac hypertrophy

Method : AAV9 were injected into mice through tail vein, 100 μl per mouse, virus titer 1×10¹² v.g/ml  

Figure 4. NEU1 overexpression in heart of mice causes cardiac hypertrophy and remodelling under physiological conditions

Customer Case 2:

State Key Laboratory of Basic and Application of Aerospace Medicine Customer Published in Circulation, IF=29.69

Title: Targeting E3 Ubiquitin-Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination

Method : AAV9 were injected into mice through intravenous, injection volume 1x10¹¹ V.g/mouse

Figure 7. Therapeutic targeting of WWP1 protects from pressure overload–induced cardiac hypertrophy via inhibiting DVL2-CaMKII-HDAC4-MEF2C pathway

Customer Case 3:

Customer of Air Force Military Medical University published in Circulation Research, IF=14.467

Title: Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection

Method : rats were intramyocardially injected 1 week prior to swim training with AAV9 at 6× 10¹⁰v.g vector genomes per rat

Figure 7. miR-342-5p was essential for exercise-induced cardioprotection