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Customer Case 1:
University of Science and Technology of China customer Published in CELL, IF=41.582 (2018)
Title: Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain
Methods: A glass micropipette was placed bilaterally into the M2 cortex or CA3 region of the hippocampus and 0.5 uL of virus was infused on each side using a pump at a rate of 50 nl/min. virus titer 1.33×1012 v.g/mL. 12 v.g/mL
Figure 5. Effects of UVB Exposure on Glutamatergic Synaptic Transmission from HPC CA3 to CA1
Customer Case 2:
Chinese Academy of Sciences customer Published in Cell Research, IF=25.617 (2018)
Title: METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation
Methods: Viruses were delivered at a rate of 0.1 µl/min, and needles were kept still for an additional 1 min before withdrawing, were bilaterally injected into the dorsal hippocampus (relative to bregma: AP = −1.9 mm, ML = ± 1.2 mm, DV = − 1.3 mm). virus titer 1.0-1.2 ×1012v.g/ml
Figure7. METTL3-mediated m6A modification in regulating long-term memory
Customer Case 3
Zhejiang University Customer Published in Nature Neuroscience, IF=24.884 (2016)
Title: Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear
Method: AAV2/9 injected 0.3–0.5 µl of virus into each location at 0.05 µl/min, were injected into the right-lateral LDT (AP, −5.2 mm from bregma; ML, −0.4 mm; DV, −3.5 mm). virus titer1.0×1012v.g/ml
Figure 4. PV+ and SOM+ interneurons in the LDT oppositely regulate innate fear
Customer Case 1:
Customer of Southern Medical University Published in CELL, IF=41.582 (2019)
Title: LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis
Method : AAV9 were injected into mice through tail vein, 100 μl per mouse, virus titer 1.0 × 1012v.g/ml
Figure 7. AAV9-LECT2-shRNA Decreases Liver Fibrosis
Customer Case 2:
Customer of Nanjing University Published in Nature Communications, IF=14.949
Title: CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
Method : AAV9 were injected into mice through intravenous, virus titer1.0 × 1012v.g/ml
Figure 8. CUGBP1 in HSCs promotes murine liver fibrosis induced by BDL
Customer Case 3:
Customer of China Pharmaceutical University Published in Nature Neuroscience, IF=24.884
Title: Angptl8 mediates food-driven resetting of hepatic circadian clock in mice
Method : AAV8 were injected into mice through tail vein, virus titer 1.0 × 1012v.g/ml
Figure 9. Angptl8 knockdown dampens the liver clock reset by food
Customer Case 1:
Customer of China Pharmaceutical University Published in European heart journal, IF=29.983
Title: Neuraminidase 1 is a driver of experimental cardiac hypertrophy
Method : AAV9 were injected into mice through tail vein, 100 μl per mouse, virus titer 1×1012 v.g/ml
Figure 4. NEU1 overexpression in heart of mice causes cardiac hypertrophy and remodelling under physiological conditions
Customer Case 2:
State Key Laboratory of Basic and Application of Aerospace Medicine Customer Published in Circulation, IF=29.69
Title: Targeting E3 Ubiquitin-Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination
Method : AAV9 were injected into mice through intravenous, injection volume 1x1011 V.g/mouse
Figure 7. Therapeutic targeting of WWP1 protects from pressure overload–induced cardiac hypertrophy via inhibiting DVL2-CaMKII-HDAC4-MEF2C pathway
Customer Case 3:
Customer of Air Force Military Medical University published in Circulation Research, IF=14.467
Title: Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection
Method : rats were intramyocardially injected 1 week prior to swim training with AAV9 at 6× 1010v.g vector genomes per rat
Figure 7. miR-342-5p was essential for exercise-induced cardioprotection
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